Nightmare Eve follows Evelyn Harris as she searches for her family in the resort town of Amherst. She has no memory of how she arrived or how long she'd been staying; her only clues: a prescription bottle of Doxepin, a wallet made of human flesh, and a teenager's warning, "Don't go out after dark!"
As she searches for her missing family, she realizes something is terribly wrong with Amherst. After curfew, a murder shakes the town and the citizens of Amherst realize their worst nightmare has returned--a serial killer claiming victims from beyond the grave.
In a race against time, Evelyn and a group of survivors seek refuge in an abandoned shop because once the sun sets, the town is plummeted into a world of nightmarish horror.
In order for Evelyn to save her family and rescue the survivors, she must solve cryptic puzzles, fight the nightmare creatures stalking the streets, and unravel the dark mysteries of Amherst's melancholy past.